Sertraline and cocaine-induced locomotion in mice. II. Chronic studies.

@article{Reith1991SertralineAC,
  title={Sertraline and cocaine-induced locomotion in mice. II. Chronic studies.},
  author={Maarten E. A. Reith and Christine T. Fischette},
  journal={Psychopharmacology},
  year={1991},
  volume={103 3},
  pages={306-13}
}
The effects of repeated treatment with the serotonin uptake blocker sertraline on cocaine-induced locomotion in female C57BL/6ByJ mice were examined in three paradigms. First, when animals were treated for 2 weeks with a daily injection of 8 mg/kg IP of sertraline (or placebo) and challenged with cocaine (25 mg/kg IP) 1 h after the final sertraline injection, their cocaine-induced locomotion was the same as that of placebo-pretreated controls. Second, animals were treated for 2 weeks with… CONTINUE READING