Sertraline Causes Strong Coronary Vasodilation: Possible Relevance for Cardioprotection by Selective Serotonin Reuptake Inhibitors

@article{Melle2004SertralineCS,
  title={Sertraline Causes Strong Coronary Vasodilation: Possible Relevance for Cardioprotection by Selective Serotonin Reuptake Inhibitors},
  author={Joost P. van Melle and Hendrik J Buikema and Maarten van den Berg and Azuwerus van Buiten and Dirk Jan van Veldhuisen and Piet W. Boonstra and Wiek H. van Gilst},
  journal={Cardiovascular Drugs and Therapy},
  year={2004},
  volume={18},
  pages={441-447}
}
Objective: Although Selective Serotonin Reuptake Inhibitors (SSRIs) are important antidepressant drugs, knowledge of their vaso active effects is limited. Vaso active effects of the SSRI sertraline were studied in rings of rat aorta, human Internal Mammary Arteries (IMAs) and in Langendorff perfused rat hearts. Methods: The effects of sertraline (0.1 to 300 μ mol ⋅ L− 1) on precontracted rat aortic and IMA rings were evaluated in organ bath chambers. Precontraction was elicited by serotonin (5… CONTINUE READING

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