Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway.

  • Si Chen, Jiekun Xuan, +5 authors Lei Guo
  • Published 2014 in
    Toxicological sciences : an official journal of…
  • DOI:10.1093/toxsci/kft254
Sertraline is generally used for the treatment of depression and is also approved for the treatment of panic, obsessive-compulsive, and posttraumatic stress disorders. Previously, using rat primary hepatocytes and isolated mitochondria, we demonstrated that sertraline caused hepatic cytotoxicity and mitochondrial impairment. In the current study, we… (More)

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