Sertoli cells improve survival of motor neurons in SOD1 transgenic mice, a model of amyotrophic lateral sclerosis.

@article{Hemendinger2005SertoliCI,
  title={Sertoli cells improve survival of motor neurons in SOD1 transgenic mice, a model of amyotrophic lateral sclerosis.},
  author={Richelle A. Hemendinger and Jay J. Wang and Saafan Z. Malik and Rafal Persinski and Jane Copeland and Dwaine F. Emerich and Paul F. Gores and Craig Halberstadt and Jeffrey Rosenfeld},
  journal={Experimental neurology},
  year={2005},
  volume={196 2},
  pages={235-43}
}
Cell replacement therapy has been widely suggested as a treatment for multiple diseases including motor neuron disease. A variety of donor cells have been tested for treatment including isolated preparations from bone marrow and embryonic spinal cord. Another cell source, Sertoli cells, have been successfully used in models of diabetes, Parkinson's disease and Huntington's disease. The ability of these cells to secrete cytoprotective proteins and their role as 'nurse cells' supporting the… CONTINUE READING

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