Sertoli cell modulates MAA-induced apoptosis of germ cells throughout voltage-operated calcium channels.

@article{Barone2004SertoliCM,
  title={Sertoli cell modulates MAA-induced apoptosis of germ cells throughout voltage-operated calcium channels.},
  author={Fortunata Barone and Salvatore Aguanno and Alessio D'Alessio and Angela D'agostino},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2004},
  volume={18 2},
  pages={353-4}
}
Spontaneous cell death by apoptosis--occurring during normal spermatogenesis in mammals--is a prominent event, which results in the loss of up to 75% of the potential number of mature spermatozoa. In the rat testis, the most conspicuous dying cells are pachytene spermatocytes, which are also the primary target of the apoptosis experimentally induced by methoxyacetic acid (MAA). In this paper, we have used clusterin expression as an indicator of germ cell apoptosis in rat seminiferous tubules… CONTINUE READING
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