Sertindole causes distinct electrocardiographic T-wave morphology changes.

  title={Sertindole causes distinct electrocardiographic T-wave morphology changes.},
  author={Jimmi Nielsen and Claus Graff and T. Hardahl and M. P. Andersen and Jens Kristoffersen and Johannes J. Struijk and Egon Toft and Jonathan M Meyer},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  volume={19 10},
Sertindole's propensity to prolong the QT interval relates to blockade of the KCNH2 (HERG) encoded Ikr potassium channel, but there has been limited detailed data on T-wave morphology changes. Digital 12-lead ECG was recorded at baseline and at steady-state in 37 patients switched to sertindole. ECG was analyzed for quantitative T-wave morphology changes and Fridericia-corrected QT duration (QTcF). Prominent T-wave morphology changes occurred during sertindole treatment and in some cases… CONTINUE READING

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