Serrated polyps of the large intestine: a molecular study comparing sessile serrated adenomas and hyperplastic polyps.

@article{Sandmeier2009SerratedPO,
  title={Serrated polyps of the large intestine: a molecular study comparing sessile serrated adenomas and hyperplastic polyps.},
  author={Dominique Sandmeier and Jean Benhattar and Patricia Geist Martin and Hanifa Bouzour{\`e}ne},
  journal={Histopathology},
  year={2009},
  volume={55 2},
  pages={206-13}
}
AIMS To compare the molecular profile of a series of sessile serrated adenomas (SSAs) and hyperplastic polyps (HPs), in order to distinguish these lesions, SSAs having a potential role in the genesis of serrated adenocarcinomas through a serrated pathway in which methylation plays a key role. METHODS AND RESULTS Twelve HPs and sixteen SSAs of the right and left colon were investigated for microsatellite instability, DNA mismatch repair genes, p53, p16, and beta-catenin expression, MLH1 and… CONTINUE READING