Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis

  title={Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis},
  author={P{\"a}ivi Laiho and Antti Kokko and Sakari Vanharanta and Reijo Salovaara and Heli Sammalkorpi and Heikki J{\"a}rvinen and J-P Mecklin and Tuomo Juhani Karttunen and Karoliina Tuppurainen and Vicente Davalos and Stuart S. Schwartz and Diego Arango and Markus J. M{\"a}kinen and Lauri A. Aaltonen},
Serrated colorectal carcinomas (CRCs) are morphologically different from conventional CRCs and have been proposed to follow a distinct pathway of CRC formation. Despite studies of single molecular events in this tumor type, the diagnosis of serrated CRC relies on morphology and the putative unique biological character of these tumors has not been established. Here we show that the gene expression profiling of 37 CRCs separated serrated and conventional CRCs into two distinct branches in… CONTINUE READING
Highly Cited
This paper has 72 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 42 extracted citations

A new evolutionary gene selection technique

2015 IEEE Congress on Evolutionary Computation (CEC) • 2015
View 6 Excerpts
Method Support
Highly Influenced

Adaptive Fuzzy Consensus Clustering Framework for Clustering Analysis of Cancer Data

IEEE/ACM Transactions on Computational Biology and Bioinformatics • 2015
View 10 Excerpts
Highly Influenced

c-Rel is a transcriptional repressor of EPHB2 in colorectal cancer.

The Journal of pathology • 2009
View 12 Excerpts
Highly Influenced

Data Mining and Big Data

Lecture Notes in Computer Science • 2016
View 10 Excerpts
Highly Influenced

An improved method for multi-objective clustering ensemble algorithm

2012 IEEE Congress on Evolutionary Computation • 2012
View 4 Excerpts
Highly Influenced

72 Citations

Citations per Year
Semantic Scholar estimates that this publication has 72 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 19 references

Am J Surg Pathol 26: 249–256

Tuppurainen K, Makinen JM, Junttila O, Liakka A, Kyllonen • 2002
View 3 Excerpts
Highly Influenced

Gastroenterology 129: 874–884

R Salovaara
Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, • 2005
View 1 Excerpt
Highly Influenced

Cancer Res 65: 10170–10173

AJ Wilson
Arango D, Laiho P, Kokko A, Alhopuro P, Sammalkorpi H, • 2005

J Pathol 207: 285–294

AP, H Tuominen
Yashiro M, Laghi L, Saito K, Carethers JM, Slezak P, • 2005

Nat Genet 36: 979–983

DO, S Tuzmen
Iino H, Jass JR, Simms LA, Young J, Leggett B, Ajioka Y • 2004

Nat Rev Genet 5: 229–237

JA Warrington
Huusko P, Ponciano-Jackson D, Wolf M, Kiefer JA, Azorsa • 2004

Genome Biol 4: R28

M Sunshine
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, • 2003

Bioinformatics 18: 1427–1431

LC Li, R. Dahiya
Am J Clin Pathol • 2002
View 1 Excerpt

Cell 111: 251–263

E Sancho, G Huls
Benjamini Y, Hochberg Y. (1995). J Roy Stat Soc Ser B 57: • 2002

Gut 51: 200–206

IC Talbot
Schwartz RA. (1978). N Engl J Med 299: 49. Semenza GL. (2003). Nat Rev Cancer 3: 721–732. Taipale J, Beachy PA. (2001). Nature 411: 349–354. Tamayo P, Slonim D, Mesirov J, Zhu Q, Kitareewan S, • 2002