Serpins in prokaryotes.

@article{Irving2002SerpinsIP,
  title={Serpins in prokaryotes.},
  author={James A Irving and Peter J M Steenbakkers and Arthur M. Lesk and Huub J M Op den Camp and Robert N. Pike and James C. Whisstock},
  journal={Molecular biology and evolution},
  year={2002},
  volume={19 11},
  pages={1881-90}
}
Members of the serpin (serine proteinase inhibitor) superfamily have been identified in higher multicellular eukaryotes (plants and animals) and viruses but not in bacteria, archaea, or fungi. Thus, the ancestral serpin and the origin of the serpin inhibitory mechanism remain obscure. In this study we characterize 12 serpin-like sequences in the genomes of prokaryotic organisms, extending this protein family to all major branches of life. Notably, these organisms live in dramatically different… CONTINUE READING

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