Serpins: structure and mechanism of action.

  title={Serpins: structure and mechanism of action.},
  author={James Travis and Amalia Guzdek and Jan Potempa and Wiesław Watorek},
  journal={Biological chemistry Hoppe-Seyler},
  volume={371 Suppl},
The Serpins are a major family of proteins, most of which are involved in the regulation of proteinase activity. Current data indicate that inhibitor function is dependent on formation of tight, but reversible binary complexes, with carbohydrate being unimportant for this function. The reaction takes place in a reactive site loop common to all Serpins, with the key residue for complex formation being in the P1 reactive site position. However, other contact residues are also involved as shown by… CONTINUE READING

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