Serpine 1 induces alveolar type II cell senescence through activating p53‐p21‐Rb pathway in fibrotic lung disease

@article{Jiang2017Serpine1I,
  title={Serpine 1 induces alveolar type II cell senescence through activating p53‐p21‐Rb pathway in fibrotic lung disease},
  author={Chunsun Jiang and Gang Liu and T. Luckhardt and V. Antony and Y. Zhou and A. Carter and V. Thannickal and Ruiming Liu},
  journal={Aging Cell},
  year={2017},
  volume={16},
  pages={1114 - 1124}
}
Senescence of alveolar type 2 (ATII) cells, progenitors of the alveolar epithelium, is implicated in the pathogeneses of idiopathic pulmonary fibrosis (IPF), an aging‐related progressive fatal lung disorder with unknown etiology. The mechanism underlying ATII cell senescence in fibrotic lung diseases, however, remains poorly understood. In this study, we report that ATII cells in IPF lungs express higher levels of serpine 1, also known as plasminogen activator inhibitor 1 (PAI‐1), and cell… Expand
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