Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog.

@article{Hamerman2002Serpin2I,
  title={Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog.},
  author={Jessica A. Hamerman and Fumitaka Hayashi and Lea A. Schroeder and Steven P Gygi and Arthur L. Haas and Lynne Hampson and Paul B. Coughlin and Ruedi Aebersold and Alan Aderem},
  journal={Journal of immunology},
  year={2002},
  volume={168 5},
  pages={2415-23}
}
After i.p. infection of mice with the intracellular bacterium Mycobacterium bovis bacillus Calmette-Guérin, macrophages recovered from the peritoneal cavity display classical signs of immune activation. We have identified a member of the serine protease inhibitor (serpin) family which is highly induced in macrophages during bacillus Calmette-Guérin infection. Serpin 2a (spi2a) expression is also induced in macrophages in vivo during infection with Salmonella typhimurium and Listeria… CONTINUE READING

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