Serotypic variations among virulent pneumococci in deposition and degradation of covalently bound C3b: implications for phagocytosis and antibody production.

@article{Hostetter1986SerotypicVA,
  title={Serotypic variations among virulent pneumococci in deposition and degradation of covalently bound C3b: implications for phagocytosis and antibody production.},
  author={Margaret K. Hostetter},
  journal={The Journal of infectious diseases},
  year={1986},
  volume={153 4},
  pages={
          682-93
        }
}
To assess serotypic variability in resistance to phagocytosis and in elicitation of antibody response among virulent pneumococci, we quantitated covalently bound C3b and analyzed the C3b degradation fragments for log-phase pneumococci of serotypes 3, 4, 6A, and 14 after opsonization for 20 and 90 min. In C3/C4-deficient agammaglobulinemic serum reconstituted with [3H]C3, covalent binding ranged from 2.9 X 10(4) to 1.5 X 10(5) C3b molecules per organism and increased at least two-fold in the… CONTINUE READING

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