Serotype-Specific Killing of Large Cell Carcinoma Cells by Reovirus

@inproceedings{Simon2017SerotypeSpecificKO,
  title={Serotype-Specific Killing of Large Cell Carcinoma Cells by Reovirus},
  author={Emily J. Simon and Morgan A. Howells and Johnasha D. Stuart and Karl W Boehme},
  booktitle={Viruses},
  year={2017}
}
Reovirus is under development as a therapeutic for numerous types of cancer. In contrast to other oncolytic viruses, the safety and efficacy of reovirus have not been improved through genetic manipulation. Here, we tested the oncolytic capacity of recombinant strains (rs) of prototype reovirus laboratory strains T1L and T3D (rsT1L and rsT3D, respectively) in a panel of non-small cell lung cancer (NSCLC) cell lines. We found that rsT1L was markedly more cytolytic than rsT3D in the large cell… CONTINUE READING
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