Serotonylation of Small GTPases Is a Signal Transduction Pathway that Triggers Platelet α-Granule Release
@article{Walther2003SerotonylationOS, title={Serotonylation of Small GTPases Is a Signal Transduction Pathway that Triggers Platelet $\alpha$-Granule Release}, author={Diego J. Walther and J. Peter and Sandra Winter and Markus H{\"o}ltje and Nils Paulmann and Maik Grohmann and Jakob Vowinckel and Victor Alamo-Bethencourt and Claudia S Wilhelm and Gudrun Ahnert-Hilger and Michael Bader}, journal={Cell}, year={2003}, volume={115}, pages={851-862} }
413 Citations
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The current state of basic biological research regarding the hemostatic and non-hemostatic functions of platelet-derived 5-HT in normal and disease conditions are highlighted and the physiological consequences of targeting platelet 5- HT functions in thrombosis, stroke, inflammation and cancer to overcome common health problems are described.
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- Biology, ChemistryMolecular and Cellular Biochemistry
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This active tRNA–miniribozyme chimera is capable of selectively cleaving native Tph1 mRNA in vivo, with concomitant downregulation of the serotonin biosynthesis, and may provide a novel and effective form of gene therapy that may be applicable to a variety of thrombotic diseases.
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