Serotonylation of Small GTPases Is a Signal Transduction Pathway that Triggers Platelet α-Granule Release

  title={Serotonylation of Small GTPases Is a Signal Transduction Pathway that Triggers Platelet α-Granule Release},
  author={D. Walther and J. Peter and Sandra Winter and M. H{\"o}ltje and Nils Paulmann and Maik Grohmann and J. Vowinckel and Victor Alamo-Bethencourt and C. Wilhelm and G. Ahnert-Hilger and Michael Bader},
  • D. Walther, J. Peter, +8 authors Michael Bader
  • Published 2003
  • Biology, Medicine
  • Cell
  • Serotonin is a neurotransmitter in the central nervous system. In the periphery, serotonin functions as a ubiquitous hormone involved in vasoconstriction and platelet function. Serotonin is synthesized independently in peripheral tissues and neurons by two different rate-limiting tryptophan hydroxylase (TPH) isoenzymes. Here, we show that mice selectively deficient in peripheral TPH and serotonin exhibit impaired hemostasis, resulting in a reduced risk of thrombosis and thromboembolism… CONTINUE READING
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