• DOI:10.1016/S0092-8674(03)01014-6
Corpus ID: 16847296

Serotonylation of Small GTPases Is a Signal Transduction Pathway that Triggers Platelet α-Granule Release

@article{Walther2003SerotonylationOS,
  title={Serotonylation of Small GTPases Is a Signal Transduction Pathway that Triggers Platelet α-Granule Release},
  author={D. Walther and J. Peter and Sandra Winter and M. H{\"o}ltje and Nils Paulmann and Maik Grohmann and J. Vowinckel and Victor Alamo-Bethencourt and C. Wilhelm and G. Ahnert-Hilger and Michael Bader},
  journal={Cell},
  year={2003},
  volume={115},
  pages={851-862}
}

D. Walther, J. Peter, +8 authors Michael Bader

Published 2003

Biology, Medicine

Cell

Serotonin is a neurotransmitter in the central nervous system. In the periphery, serotonin functions as a ubiquitous hormone involved in vasoconstriction and platelet function. Serotonin is synthesized independently in peripheral tissues and neurons by two different rate-limiting tryptophan hydroxylase (TPH) isoenzymes. Here, we show that mice selectively deficient in peripheral TPH and serotonin exhibit impaired hemostasis, resulting in a reduced risk of thrombosis and thromboembolism… CONTINUE READING

View on Elsevier

doi.org

Save to Library

Create Alert

Cite

Launch Research Feed