Serotoninergic system in hamster skin.

  title={Serotoninergic system in hamster skin.},
  author={Andrzej T Slominski and Alexander Pisarchik and Igor Semak and Trevor W. Sweatman and Andre Szczesniewski and Jacobo Wortsman},
  journal={The Journal of investigative dermatology},
  volume={119 4},
We have cloned the tryptophan hydroxylase cDNA from hamster pituitary and demonstrated its expression in the skin, melanotic and amelanotic melanomas, spleen, heart, and the eye. We further demonstrated that skin, melanomas, spleen, pituitary, and eye but not heart expressed arylalkylamine N-acetyltransferase mRNA. The cutaneous expression of the arylalkylamine N-acetyltransferase gene was accompanied by enzymatic activity for the conversion of serotonin and tryptamine to N-acetylserotonin and… CONTINUE READING


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