Serotoninergic and melatoninergic systems are fully expressed in human skin

@article{Slominski2002SerotoninergicAM,
  title={Serotoninergic and melatoninergic systems are fully expressed in human skin},
  author={Andrzej T. Slominski and Alexander V. Pisarchik and Igor V Semak and Trevor W. Sweatman and Jacobo Wortsman and Andre Szczesniewski and George Slugocki and John Mcnulty and S{\"o}bia Kauser and Desmond J. Tobin and Chen Jing and Olle Johansson},
  journal={The FASEB Journal},
  year={2002},
  volume={16}
}
We investigated the cutaneous expression of genes and enzymes responsible for the multistep conversion of tryptophan to serotonin and further to melatonin. Samples tested were human skin, normal and pathologic (basal cell carcinoma and melanoma), cultured normal epidermal and follicular melanocytes, melanoma cell lines, normal neonatal and adult epidermal and follicular keratinocytes, squamous cell carcinoma cells, and fibroblasts from dermis and follicular papilla. The majority of the samples… 
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258 Citations

Tryptophan hydroxylase expression in human skin cells.

On the role of melatonin in skin physiology and pathology

It is proposed that melatonin (synthesized locally or delivered topically) could counteract or buffer external (environmental) or internal stresses to preserve the biological integrity of the organ and to maintain its homeostasis.

Serotoninergic system in hamster skin.

A cutaneous pathway displaying capabilities for serotonin biosynthesis and/or its metabolism to N-acetylserotonin in rodent skin is uncovered, as serotonin has powerful vasodilator, immunomodulator, and growth factor actions, and this pathway could be involved in skin physiology and/ or pathology.

Characterization of serotonin and N‐acetylserotonin systems in the human epidermis and skin cells

A serotonin‐NAS system in human skin that is a part of local neuroendocrine system regulating skin homeostasis is characterized and produced endogenously in the epidermal, dermal, and adnexal compartments of human skin and in cultured skin cells.

The cutaneous serotoninergic/melatoninergic system: securing a place under the sun

The widespread expression of a cutaneous seorotoninergic/melatoninergic system indicates considerable selectivity of action to facilitate intra‐, auto‐, or paracrine mechanisms that define and influence skin function in a highly compartmentalized manner.

Characterization of the serotoninergic system in the C57BL/6 mouse skin.

Mouse skin has the molecular and biochemical apparatus necessary to produce and metabolize serotonin and N-acetylserotonin, and its activity is determined by topography, physiological status of the skin, cell type and mouse strain.

Serotoninergic and melatoninergic systems are expressed in mouse embryonic fibroblasts NIH3T3 cells.

Evidence is provided that the NIH3T3 cells can synthesize intrinsic serotonin and melatonin and express key enzymes related biosynthetic pathways.

Melatonin exerts oncostatic capacity and decreases melanogenesis in human MNT‐1 melanoma cells

In vitro assessment indicates an oncostatic capacity of melatonin in time‐dependent manner in highly pigmented MNT‐1 melanoma cells and primary, electron paramagnetic resonance (EPR) spectroscopy demonstrated that melatonin reduced melanin content.

The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19)

Specific Urinary Metabolites in Malignant Melanoma

High-performance liquid chromatography detection of metabolites of L-tyrosine and tryptophan in the urine of melanoma patients may play a significant role in diagnostics as well as a therapeutic strategy of melanomas cancer.
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