• DOI:10.1002/CNE.903180102
• Corpus ID: 23190313

Serotoninergic, noradrenergic, and peptidergic innervation of Onuf's nucleus of normal and transected spinal cords of baboons (papio papio)

@article{Rajaofetra1992SerotoninergicNA,
  title={Serotoninergic, noradrenergic, and peptidergic innervation of Onuf's nucleus of normal and transected spinal cords of baboons (papio papio)},
  author={Narivelo Rajaofetra and J G Passagia and Lionel N.J.L. Marlier and Philippe Poulat and Fr{\'e}d{\'e}ric Pellas and Françoise Sandillon and B. Verschuere and De Gouy and Michel Geffard and Alain Privat},
  journal={Journal of Comparative Neurology},
  year={1992},
  volume={318}
}

• N. Rajaofetra, J. Passagia, +7 authors A. Privat
• Published 1 April 1992
• Biology
• Journal of Comparative Neurology

We have investigated with light and electron microscope immunocytochemistry the aminergic and peptidergic innervation of Onuf's nucleus in adult baboons. This nucleus, located in the ventrolateral part of the sacral spinal cord (S2 and S3), is considered to control urethral and anal sphincters and penile muscles. By comparison of intact and transected spinal cords, we have found that serotoninergic innervation has two origins: first, supraspinal, innervating the whole nucleus, with a possible predominance in the dorsal half; and second, intraspinal, corresponding to the ventral half of the nucleus. Thyrotropin‐releasing hormone innervation appears largely coincident with serotonin, both in intact and transected spinal cords. Noradrenaline is exclusively of supraspinal origin, as attested by its disappearance below the level of the section. Substance P, calcitonin genex‐related peptide, and Leux‐ and Metx‐enkephalin, which profusely innervate Onuf's nucleus, are on the contrary not affected by the transection. They most likely originate from the cord itself or the dorsal root ganglia. Thus, Onuf's nucleus innervation in the baboon arises both from supraspinal and intraspinal sources.