Serotoninergic, noradrenergic, and peptidergic innervation of Onuf's nucleus of normal and transected spinal cords of baboons (papio papio)

@article{Rajaofetra1992SerotoninergicNA,
  title={Serotoninergic, noradrenergic, and peptidergic innervation of Onuf's nucleus of normal and transected spinal cords of baboons (papio papio)},
  author={Narivelo Rajaofetra and Jean Guy Passagia and Lionel N.J.L. Marlier and Philippe Poulat and Fr{\'e}d{\'e}ric Pellas and Françoise Sandillon and B. Verschuere and De Gouy and Michel Geffard and Alain Privat},
  journal={Journal of Comparative Neurology},
  year={1992},
  volume={318}
}
We have investigated with light and electron microscope immunocytochemistry the aminergic and peptidergic innervation of Onuf's nucleus in adult baboons. This nucleus, located in the ventrolateral part of the sacral spinal cord (S2 and S3), is considered to control urethral and anal sphincters and penile muscles. By comparison of intact and transected spinal cords, we have found that serotoninergic innervation has two origins: first, supraspinal, innervating the whole nucleus, with a possible… Expand
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Serotoninergic, peptidergic and GABAergic innervation of the ventrolateral and dorsolateral motor nuclei in the cat S1/S2 segments: An immunofluorescence study
TLDR
Study of serotoninergic, peptidergic and GABAergic innervation of the ventrolateral and dorsolateral nuclei of the cat spinal cord suggested an exclusive supraspinal origin for substance P-immunoreactive fibers. Expand
Immunohistochemical examination of intraspinal serotonin neurons and fibers in the chicken lumbar spinal cord and coexistence with Leu-enkephalin
TLDR
Intraspinal serotonin-positive cells and fibers were examined in the chicken lumbar spinal cord following removal of descending serotonin fibers by spinal transection and co-localization of Leu-enkephalin immunoreactivity was examined using a double immunofluorescence labeling technique. Expand
Enkephalin-, thyrotropin-releasing hormone- and substance P-immunoreactive axonal innervation of the ventrolateral dendritic bundle in the cat sacral spinal cord: An ultrastructural study
The distribution and synaptic arrangement of thyrotropin-releasing hormone-, substance P- and enkephalin-immunoreactive axonal boutons have been studied in the ventrolateral nucleus (Onuf's nucleus)… Expand
5-Hydroxytryptamine2C receptors on spinal neurons controlling penile erection in the rat
TLDR
The results indicate that all parasympathetic preganglionic neurons and their related interneurons which contribute to the innervation of cavernosal tissue bear 5-hydroxytryptamine2C receptors. Expand
Distribution of dopamine immunoreactivity in the rat, cat, and monkey spinal cord
TLDR
It is concluded that DA is widely distributed within the spinal cord, with few differences between species, emphasizing that DA plays an important role as one of the monoamines that influences sensory input as well as autonomic and motor output at the spinal level. Expand
Serotonin 5‐HT2A and 5‐HT5A receptors are expressed by different motoneuron populations in rat Onuf's nucleus
TLDR
Comparisons show a preferential localization of 5‐HT2A and 5‐ HT5A receptors to motoneurons controlling the striated muscles located at the penile crus and sphincter muscles, respectively, suggesting a specific serotoninergic control on different pelvic functions. Expand
Serotonin and norepinephrine involvement in efferent pathways to the urethral rhabdosphincter: implications for treating stress urinary incontinence.
TLDR
Boosting the effects of 5-HT and norepinephrine (NE) to enhance sphincter activity could be clinically promising for improving the symptoms of stress urinary incontinence. Expand
Anatomical study of serotonergic innervation and 5-HT1A receptor in the human spinal cord
TLDR
A preliminary mapping of serotonergic processes and serotonin-lA (5-HT1A) receptors in thoracic and lumbar segments of the human spinal cord is performed and pave the way for local specific therapies involving cellular and/or pharmacological tools targeting theserotonergic system. Expand
Catecholaminergic projections onto spinal neurons destined to the pelvis including the penis in rat
TLDR
In adult male rats, the catecholaminergic innervation of spinal neurons controlling lower urogenital tissues and regulating penile erection is evidenced by combining retrograde tracing techniques and immunohistochemistry against synthetic enzymes of noradrenaline and adrenaline. Expand
Changes in substance P and 5-HT binding in the spinal cord dorsal horn and lamina 10 after dorsolateral funiculus lesions
TLDR
The bilateral effects seen in the present study are consistent with the bilaterality of descending thoracic DLF projections demonstrated by the Fink-Heimer method. Expand
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