Serotonin4 (5-HT4) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action
@article{Lucas2007Serotonin4R, title={Serotonin4 (5-HT4) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action}, author={Guillaume Lucas and Vladimir V. Rymar and Jenny Du and Ouissame Mnie-Filali and Christina F. Bisgaard and Stella Manta and Laura Lamb{\'a}s-se{\~n}as and Ove Wiborg and Nasser Haddjeri and Graciela Piñeyro and Abbas F. Sadikot and Guy Debonnel}, journal={Neuron}, year={2007}, volume={55}, pages={712-725} }
302 Citations
Serotonin 2C receptor antagonists induce fast-onset antidepressant effects
- Psychology, BiologyMolecular Psychiatry
- 2014
The findings reveal that 5-HT2C antagonists are putative fast-onset antidepressants, which act through enhancement of mesocortical dopaminergic signaling.
Serotonin 2C receptor antagonists induce fast-onset antidepressant effects
- Psychology, BiologyMolecular Psychiatry
- 2014
The findings reveal that 5-HT2C antagonists are putative fast-onset antidepressants, which act through enhancement of mesocortical dopaminergic signaling.
Selective Serotonin Reuptake Inhibitors Potentiate the Rapid Antidepressant-Like Effects of Serotonin4 Receptor Agonists in the Rat
- Biology, PsychologyPloS one
- 2010
In acute conditions, the 5-HT4 agonist prucalopride was able to counteract the inhibitory effect of the selective serotonin reuptake inhibitors (SSRI) fluvoxamine and citalopram on 5- HT neuron impulse flow, in Dorsal Raphé Nucleus cells selected for their high basal discharge.
Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy
- Psychology, BiologyNeuropsychopharmacology
- 2011
Findings indicate that the 5-HT7 receptor antagonists may represent a new class of antidepressants with faster therapeutic action than the commonly prescribed antidepressant fluoxetine.
Role of 5-HT3 Receptors in the Antidepressant Response
- Psychology, BiologyPharmaceuticals
- 2011
Major advances in the research of 5-HT3 receptor's roles in neuropsychiatric disorders are reported, with special emphasis on mood and anxiety disorders.
5-HT2B receptors are required for serotonin-selective antidepressant actions
- Biology, PsychologyMolecular Psychiatry
- 2012
The 5-HT2B receptor appears to positively modulate serotonergic activity and to be required for the therapeutic actions of SSRIs, and should be considered as a new tractable target in the combat against depression.
5-HT7 receptor antagonists as a new class of antidepressants.
- Psychology, BiologyDrug news & perspectives
- 2007
This review summarizes recent data that put emphasis on the putative antidepressant properties of selective 5-HT(7) receptor antagonists and the use of such ligands seems very promising to elaborate novel generations of antidepressants that surpass the efficacy and onset of action limitations of existing antidepressants.
The peptidic antidepressant spadin interacts with prefrontal 5-HT4 and mGluR2 receptors in the control of serotonergic function
- BiologyBrain Structure and Function
- 2014
The results indicate that spadin, as a natural compound, constitutes a very good candidate to explore the “glutamatergic path” of fast-acting AD research, and provide the first evidence of 5-HT depolarization block, showing that the combination of5-HT activators for strategies of AD augmentation should be performed with extreme caution.
Rapid Anxiolytic Effects of a 5-HT4 Receptor Agonist Are Mediated by a Neurogenesis-Independent Mechanism
- Psychology, BiologyNeuropsychopharmacology
- 2014
5-HT4 receptor stimulation could represent an innovative and rapid onset therapeutic approach to treat depression with comorbid anxiety and chronic treatment with GR125487 prevented both anxiolytic/antidepressant-like and neurogenic effects of fluoxetine.
Serotonin receptors involved in antidepressant effects.
- Biology, PsychologyPharmacology & therapeutics
- 2013
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