Serotonin2C receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and electrophysiological analysis in the rat

@article{Gobert2000Serotonin2CRT,
  title={Serotonin2C receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and electrophysiological analysis in the rat},
  author={Alain P. Gobert and Jean Michel Rivet and Françoise Lejeune and Adrian Newman-Tancredi and Agnes Adhumeau‐Auclair and Jean Paul Nicolas and Laetitia Cistarelli and Christophe Melon and Mark J Millan},
  journal={Synapse},
  year={2000},
  volume={36}
}
The present study evaluated, via a combined electrophysiological and dialysis approach, the potential influence of serotonin (5‐HT)2C as compared to 5‐HT2A and 5‐HT2B receptors on dopaminergic, adrenergic, and serotonergic transmission in frontal cortex (FCX). Whereas the selective 5‐HT2A antagonist MDL100,907 failed to modify extracellular levels of dopamine (DA), noradrenaline (NA) or 5‐HT simultaneously quantified in single dialysate samples of freely‐moving rats, the 5‐HT2B/5‐HT2C… 
Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of α2‐adrenergic and serotonin2C receptors: a comparison with citalopram
TLDR
In contrast to citalopram, mirtazapine reinforces frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission, and reflects antagonist properties at α2A‐AR and 5‐HT2C receptors.
The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity
TLDR
Results indicate that the activity of VTA DA neurones is under the excitatory control of 5‐HT2A receptors in the mPFC, which may help in the understanding of the therapeutic action of atypical antipsychotics.
Striatal serotonin 2C receptors decrease nigrostriatal dopamine release by increasing GABA‐A receptor tone in the substantia nigra
TLDR
A role for 5‐HT2C receptors regulating striatal DA release that is highly localized is suggested, which may represent a primary site of action that is mediated by the actions on GABAergic activity in the SN.
Region‐dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors
TLDR
It is demonstrated that both VTA and NAc 5‐HT2CRs participate in the inhibitory control exerted by 5-HT2 CRs on accumbal DA release, and that the NAc shell may represent a primary action site for the CA of 5‐ HT2CRS.
Evidence that central 5‐HT2A and 5‐HT2B/C receptors regulate 5‐HT cell firing in the dorsal raphe nucleus of the anaesthetised rat
TLDR
Recordings of 5‐HT neurones in the dorsal raphe nucleus of anaesthetised rats indicate that the inhibition of 5-HT cell firing induced by systemic administration of DOI and DOB is mediated predominantly by the5‐HT2A receptor‐subtype, but that 5‐ HT2B/C receptors also play a minor role.
Modulation of dopamine release by striatal 5‐HT2C receptors
TLDR
The results suggest that the nigrostriatal system is regulated by 5‐HT2C receptors localized in the dorsal striatum, and that serotonin (5‐HT) modulates striatal and prefrontocortical DA concentrations may lead to improvements in the treatment of diverse syndromes.
Pindolol excites dopaminergic and adrenergic neurons, and inhibits serotonergic neurons, by activation of 5‐HT1A receptors
TLDR
Through engagement of 5‐HT1A receptors, pindolol inhibits serotonergic, and activates dopaminergic and adrenergic, neurons in anaesthetized rats, and may contribute to its influence upon mood, both alone and in association with antidepressant agents.
Evidence for the Preferential Involvement of 5-HT2A Serotonin Receptors in Stress- and Drug-Induced Dopamine Release in the Rat Medial Prefrontal Cortex
TLDR
Results indicate that stimulation of cortical 5-HT2A receptors increases the release of dopamine from the mesocortical system, and suggest that this effect may be mediated by increases in glutamate release from corticotegmental projections to the VTA.
Regulation of striatal neuropeptide mRNAs: Effects of the 5‐HT2 antagonist SR46349B in adult rats with a neonatal 6‐hydroxydopamine lesion
TLDR
It is suggested that SR46349B indirectly decreases PPE mRNA levels in striatopallidal neurons in intact animals through a desinhibition of DA neuron activity, further evidenced by the lack of PPE RNA changes in the DA lesioned striatum despite the up‐regulation of 5‐HT2 receptor transmission induced in this model.
Flibanserin, a potential antidepressant drug, lowers 5‐HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5‐HT1A receptors
TLDR
The results show that the stimulation of 5‐ HT1A receptors plays a major role in the effect of flibanserin on brain extracellular 5‐HT, DA and NA.
...
...

References

SHOWING 1-10 OF 82 REFERENCES
Potentiation of the Fluoxetine‐Induced Increase in Dialysate Levels of Serotonin (5‐HT) in the Frontal Cortex of Freely Moving Rats by Combined Blockade of 5‐HT1A and 5‐HT1B Receptors with WAY 100,635 and GR 127,935
TLDR
5‐HT1A/1B antagonism may represent a novel strategy for the improvement in the therapeutic profile of 5‐ HT reuptake inhibitor antidepressant agents and that 5‐HT may be primarily involved in such interactions.
Evidence that 5‐HT2 receptor activation decreases noradrenaline release in rat hippocampus in vivo
TLDR
The data suggest that in vivo, noradrenaline release in hippocampus is inhibited by 5‐HT2 receptor activation, and this effect is probably associated with a decrease innoradrenergic neuronal activity.
Blockade of Striatal 5‐Hydroxytryptmine2 Receptors Reduces the Increase in Extracellullar Concentrations of Dopamine Produced by the Amphhetamine analogue 3,4‐Methylenedioxymethamphetamine
TLDR
5‐HT2 receptors located in the striatum augment the release of dopamine produced by high doses of MDMA, and appear to be located on nondopaminergic elements of thestriatum.
Modulation of the firing activity of noradrenergic neurones in the rat locus coeruleus by the 5‐hydroxtryptamine system
TLDR
The data support the notion that the 5‐HT system tonically modulates NA neurotransmission since the lesion of 5‐ HT neurones enhanced the LC NA neurones firing activity and the suppressant effect of WAY 100635 on the firing activity ofNA neurones was abolished by this lesion.
Differential Actions of Serotonin, Mediated by 5-HT1Band 5-HT2C Receptors, on GABA-Mediated Synaptic Input to Rat Substantia Nigra Pars Reticulata Neurons In Vitro
TLDR
Serotonin can both depolarize and disinhibit SNr neurons via 5-HT2C and5-HT1B receptors, respectively, but excitation may be limited by GABA released from axon collaterals, while spontaneous tetrodotoxin-sensitive GABAA synaptic currents were increased in frequency but reduced in frequency by serotonin.
...
...