Serotonin2A receptor-like immunoreactivity in rat cerebellar Purkinje cells

  title={Serotonin2A receptor-like immunoreactivity in rat cerebellar Purkinje cells},
  author={Toru Maeshima and Fumihiro Shutoh and Shun Hamada and Kouji Senzaki and Kayoko Hamaguchi-Hamada and Ryuzo Ito and Nobuo Okado},
  journal={Neuroscience Letters},

Cellular and subcellular distribution of the serotonin 5‐HT2A receptor in the central nervous system of adult rat

Following immunoperoxidase or silver‐intensified immunogold labeling, neuronal, somatodendritic, and/or axonal immunoreactivity was detected in numerous brain regions, including all those in which ligand binding sites and 5‐HT2A mRNA had previously been reported.

Expression of serotonin 5‐HT2A receptors in the human cerebellum and alterations in schizophrenia

Cerebellar 5‐HT2AR gene products (mRNA, protein, binding sites) are expressed in the human cerebellum at nonnegligible levels; this bears upon 5‐ HT2AR imaging studies which use the cerebellums as a reference region.

Cellular and Subcellular Localization of Serotonin Receptors in the Central Nervous System

This review summarizes much of the available data on the cellular and subcellular distribution of serotonin (5-hydroxytryptamine [5-HT]) receptors in the mammalian central nervous system and provides a meaningful demonstration of the wealth of information to be gained from this methodological approach.

Book Review: Serotonergic Neuromodulation in the Cerebellar Cortex: Cellular, Synaptic, and Molecular Basis

  • S. Dieudonné
  • Biology, Psychology
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2001
The peculiar axonal projection and specific interneuronal targets of the Lugaro cells suggest that the action of serotonin might occur upstream of Purkinje cells through a resetting of the computational properties of the cerebellar cortex.

Distinct Temporal Expression of 5-HT1A and 5-HT2A Receptors on Cerebellar Granule Cells in Mice

A novel role for serotonin in controlling function of the cerebellum via 5-HT2A receptors expressed by cerebellar granule cells is shown, which enhances short-term synaptic plasticity at the parallel fibre–Purkinje cell synapse.