Serotonin2 agonist administration down-regulates rat brain serotonin2 receptors.

@article{Buckholtz1988Serotonin2AA,
  title={Serotonin2 agonist administration down-regulates rat brain serotonin2 receptors.},
  author={N. Buckholtz and D. Zhou and D. X. Freedman},
  journal={Life sciences},
  year={1988},
  volume={42 24},
  pages={
          2439-45
        }
}
Daily administration of D-lysergic acid diethylamide (LSD) was previously shown to decrease serotonin2 (5-HT2) receptor binding in rat brain. Recently, 4-substituted derivatives of 1-(2,5-dimethoxyphenyl)-2-aminopropane, the substitution being with either iodine (DOI) or bromine (DOB), have been suggested to be relatively selective 5-HT2 agonists. These compounds share common behavioral and neurophysiological effects with LSD, suggested to be 5-HT2 receptor mediated, and the purpose of the… Expand
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