Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative.

@article{Zhou2002SerotoninUI,
  title={Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative.},
  author={Feng Chao Zhou and Klaus-Peter Lesch and Dennis L. Murphy},
  journal={Brain research},
  year={2002},
  volume={942 1-2},
  pages={109-19}
}
Monoamine neurons are believed to use neuronal-specific transporters to remove their own transmitters from the extracellular space and thus terminate transmission to postsynaptic neurons. We report here, for the first time, conclusive evidence that a cross clearance of serotonin into dopamine neurons exists. Such alternative uptake by different neurons is adopted under circumstances when their own transporter function is no longer adequate. When the serotonin transporter (5-HTT) is disrupted in… CONTINUE READING