Serotonin unmasks functional NK-2 receptors in vagal sensory neurones of the guinea-pig.

  title={Serotonin unmasks functional NK-2 receptors in vagal sensory neurones of the guinea-pig.},
  author={Kimberly A Cisneros Moore and Gayle E Taylor and Daniel Weinreich},
  journal={The Journal of physiology},
  volume={514 ( Pt 1)},
1. The regulation of substance P (SP) responsiveness in acutely isolated nodose neurones from adult guinea-pigs was investigated using standard intracellular recording techniques. 2. In control neurones, SP produced no measurable electrophysiological effects. However, following incubation with serotonin (5-HT, 10 microM), 64% of neurones were depolarized by 10 +/- 0.6 mV (n = 84 of 132 neurones) by SP (100 nM). 5-HT-induced SP responses were inhibited by SR48968 (100 nM, n = 6), a neurokinin 2… CONTINUE READING


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