Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652.

@article{Simpson2003SerotoninTI,
  title={Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652.},
  author={H. Blair Simpson and Ilise D Lombardo and Mark Slifstein and Henry Y. H. Huang and Dah Ren Hwang and Anissa Abi-Dargham and Michael R. Liebowitz and Marc Laruelle},
  journal={Biological psychiatry},
  year={2003},
  volume={54 12},
  pages={1414-21}
}
BACKGROUND Serotonergic abnormalities have been hypothesized to contribute to obsessive-compulsive disorder (OCD). This study examined whether brain serotonin transporter (SERT) availability is altered in OCD using positron emission tomography (PET) and the SERT PET radiotracer [(11)C]McN 5652. METHODS Eleven OCD subjects, free of psychiatric medications and comorbid depression, and 11 matched healthy control subjects underwent PET scans following injection of [(11)C]McN 5652 and magnetic… CONTINUE READING