Serotonin transporter occupancy by escitalopram and citalopram in the non-human primate brain: a [11C]MADAM PET study

@article{Finnema2015SerotoninTO,
  title={Serotonin transporter occupancy by escitalopram and citalopram in the non-human primate brain: a [11C]MADAM PET study},
  author={Sjoerd J. Finnema and Christer Halldin and Benny Bang-Andersen and Christoffer Bundgaard and Lars Farde},
  journal={Psychopharmacology},
  year={2015},
  volume={232},
  pages={4159-4167}
}
A number of serotonin receptor positron emission tomography (PET) radioligands have been shown to be sensitive to changes in extracellular serotonin concentration, in a generalization of the well-known dopamine competition model. High doses of selective serotonin reuptake inhibitors (SSRIs) decrease serotonin receptor availability in monkey brain, consistent with increased serotonin concentrations. However, two recent studies on healthy human subjects, using a single, lower and clinically… CONTINUE READING