Serotonin transporter null mutation and sexual behavior in female rats: 5-HT1A receptor desensitization.

@article{Snoeren2010SerotoninTN,
  title={Serotonin transporter null mutation and sexual behavior in female rats: 5-HT1A receptor desensitization.},
  author={Eelke M S Snoeren and Johnny S.W. Chan and Astrid Bovens and Edwin Cuppen and Marcel D. Waldinger and Berend Olivier and Ronald S. Oosting},
  journal={The journal of sexual medicine},
  year={2010},
  volume={7 7},
  pages={2424-34}
}
INTRODUCTION Serotonin plays a key role in sexual behavior. In serotonin transporter (SERT) knockout rats (-/-), basal extracellular 5-HT levels are considerably increased, indicating a serotonergic disturbance. Heterozygous SERT(+/-) rats express 50% of SERT in comparison to wild-type rats and may therefore model the s/s phenotype of the human SERT promoter (5-HTTLPR) polymorphism. AIM In the present study, we used both homozygote and heterozygote SERT knockout and wild-type rats (+/+) to… CONTINUE READING
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