Serotonin transporter genotype x construction stress interaction in rats

  title={Serotonin transporter genotype x construction stress interaction in rats},
  author={Pieter Schipper and Lourens J. P. Nonkes and Peter Karel and Amanda J Kiliaan and Judith R Homberg},
  journal={Behavioural Brain Research},
A well-known example for gene x environment interactions in psychiatry is the one involving the low activity (s) allelic variant of the serotonin transporter (5-HTT) promoter polymorphism (5-HTTLPR) that in the context of stress increases risk for depression. In analogy, 5-HTT knockout rodents are highly responsive to early life, but also adult external stressors, albeit conflicting data have been obtained. In our study on emotion and cognition using homozygous 5-HTT knockout (5-HTT(-/-)) and… CONTINUE READING
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