Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism.

@article{Sen2004SerotoninTA,
  title={Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism.},
  author={Srijan Sen and Sandra M. Villafuerte and Randolph M. Nesse and Scott F. Stoltenberg and Jeffrey Hopcian and Lillian Gleiberman and Alan B. Weder and Margit Burmeister},
  journal={Biological psychiatry},
  year={2004},
  volume={55 3},
  pages={244-9}
}
BACKGROUND A tendency to experience negative affect, as measured by the neuroticism component of the Neuroticism, Extraversion, and Openness Personality Inventory (NEO-PI), is a trait marker for major depression. Epidemiologic studies indicate a strong genetic component, but to date few specific genetic variants have been definitively implicated. A serotonin transporter promoter polymorphism (5-HTTLPR) has been extensively studied in neuroticism and several psychiatric disorders, with… CONTINUE READING