Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine

@article{Whale2000SerotoninT,
  title={Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine},
  author={Richard Whale and Digby J Quested and Derek Laver and Paul J. Harrison and Philip J. Cowen},
  journal={Psychopharmacology},
  year={2000},
  volume={150},
  pages={120-122}
}
Rationale: A 44-base-pair insertion/deletion polymorphism in the promoter region of the human serotonin (5-HT) transporter (5-HTT) gene gives rise to a biallelic polymorphism designated long (l) and short (s). The s variant is associated with a lower expression of 5-HTT sites and a reduced efficiency of 5-HT reuptake. Objective: The aim of the present study was to determine whether the increase in brain 5-HT function produced by acute 5-HT reuptake blockade is influenced by the 5-HTT promoter l… CONTINUE READING

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Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets

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