Serotonin toxicity: a practical approach to diagnosis and treatment.

  title={Serotonin toxicity: a practical approach to diagnosis and treatment.},
  author={Geoffrey K Isbister and Nicholas Alan Buckley and Ian McGregor Whyte},
  journal={The Medical journal of Australia},
  volume={187 6},
Excess serotonin in the central nervous system leads to a condition commonly referred to as the serotonin syndrome, but better described as a spectrum of toxicity - serotonin toxicity. Serotonin toxicity is characterised by neuromuscular excitation (clonus, hyperreflexia, myoclonus, rigidity), autonomic stimulation (hyperthermia, tachycardia, diaphoresis, tremor, flushing) and changed mental state (anxiety, agitation, confusion). Serotonin toxicity can be: mild (serotonergic features that may… CONTINUE READING
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Sublingual olanzapine for the treatment of serotonin syndrome [abstract

  • R Boddy, RP Dowsett, D. Jeganathan
  • Clin Toxicol
  • 2006

Serotonin toxicity / syndrome

  • IM Whyte
  • 2004

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  • Wilkins
  • J Clin Psychiatry
  • 2004

Use of sublingual olanzapine in serotonin syndrome [abstract

  • R Boddy, R Ali, R. Dowsett
  • J Toxicol Clin Toxicol
  • 2004

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