Serotonin syndrome with sertraline and methylphenidate in an adolescent.

@article{Trkolu2015SerotoninSW,
  title={Serotonin syndrome with sertraline and methylphenidate in an adolescent.},
  author={Serhat T{\"u}rkoğlu},
  journal={Clinical Neuropharmacology},
  year={2015}
}
To the Editor: Serotonin syndrome (SS) is a potentially life-threatening condition associated with increased serotonergic activity in the central and peripheral nervous systems. It is often described as a clinical triad of mental status changes, neuromuscular abnormalities, and autonomic dysfunction. This triad is thought to be caused by excessive stimulation of 5-HT1A and 5-HT2 receptors. Although the symptomsmay not all be present in the patient at the same time, there is actually a spectrum… Expand
Serotonin Syndrome in Children and Adolescents Exposed to Selective Serotonin Reuptake Inhibitors - A Review of Literature.
  • Siqi Xuev, A. Ickowicz
  • Medicine
  • Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent
  • 2021
TLDR
Serotonin syndrome is a severe adverse drug reaction associated with SSRI, and can be associated with diverse presentations in the pediatrics population and diagnostic challenges, and Clinicians are recommended to be vigilant in the monitoring and recognition of serotonin syndrome. Expand
Case 2: Agitation and Abnormal Movements in a 14-year-old Boy
TLDR
A 14-year-old boy with attention-deficit/hyperactivity disorder, depression, autism spectrum disorder, and astrocytoma presents to the emergency department (ED) with 2 days of abnormal movements: facial twitching, jaw stiffness, and torticollis, progressing to whole-body tremors, agitation, diaphoresis, and altered mental status. Expand
ADHD With Comorbid Bipolar Disorders: A Systematic Review of Neurobiological, Clinical And Pharmacological Aspects Across The Lifespan.
TLDR
A systematic review of the scientific literature on the neurobiological, clinical features and current pharmacological management of ADHD comorbid with BDs across the entire lifespan, with a major focus on the adulthood. Expand
Lifetime evolution of ADHD treatment
TLDR
A naturalistic review to review and comment on the available literature of ADHD treatment across the lifespan finds stimulants are endowed of a prompt efficacy and safety, whilst non-stimulants are useful when a substance abuse history is detected. Expand
Inter-class Concomitant Pharmacotherapy in Medicaid-Insured Youth Receiving Psychiatric Residential Treatment
TLDR
Findings support the practice of deprescribing and underscore the need for further research on the prevalence of concomitant pharmacotherapy in PRTFs. Expand

References

SHOWING 1-10 OF 11 REFERENCES
Treatment of the serotonin syndrome with cyproheptadine.
TLDR
The role of specific serotonin receptor antagonists such as cyproheptadine in the treatment of the serotonin syndrome remains to be delineated and its use should be considered an adjunct to supportive care. Expand
Serotonin syndrome.
TLDR
The authors put serotonin syndrome into historical context, discuss its pathophysiology, review in detail its clinical presentations, diagnostic criteria, differential diagnosis and treatment, and focus on drugs that most often cause serotonin syndrome and the gene polymorphisms involved in the metabolism of these drugs. Expand
Serotonin syndrome: a brief review.
TLDR
A 50-year-old man was admitted to hospital with hyperhidrosis, nausea, vomiting and diarrhea and the dose of fluoxetine had just been increased. Expand
Recognition and treatment of serotonin syndrome.
  • C. Frank
  • Medicine
  • Canadian family physician Medecin de famille canadien
  • 2008
TLDR
Despite the common use of medications with direct or indirect serotonergic effects, many physicians are not aware of the presentation and management of serotonin excess. Expand
The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity.
TLDR
Decision rules (the Hunter Serotonin Toxicity Criteria) were developed that were simpler, more sensitive to serotonin toxicity and less likely to yield false positives. Expand
Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data
TLDR
A meta-analysis of data from randomised controlled trials that evaluated an SSRI versus placebo in participants aged 5-18 years and that were published in a peer-reviewed journal or were unpublished and included in a review by the Committee on Safety of Medicines indicated that risks could outweigh benefits of these drugs to treat depression in children and young people. Expand
A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study.
TLDR
The emerging data of favorable therapeutic effects of ADHD treatment with d-MPH may be underpinned by affinity and potential pharmacologic effects at NET and DAT sites, as well as sites relevant to serotonergic neurotransmission that may modulate mood, cognition, and motor behavior. Expand
Effects of Methylphenidate on Extracellular Dopamine, Serotonin, and Norepinephrine: Comparison with Amphetamine
TLDR
The hypothesis that a stimulant‐induced increase in serotonin is necessary for the appearance of stereotyped behaviors is not supported, as methylphenidate promotes a dose‐dependent behavioral profile that is very comparable to that of amphetamine. Expand
Selective serotonin reuptake inhibitors in childhood depression : systematic review of 2015 Wolters Kluwer Health , Inc . All rights re published versus unpublished data
  • Lancet
  • 2004
Selective serotonin reuptake inhibitors in childhood depression: systematic review of 2015
  • Wolters Kluwer Health, Inc. All rights re published versus unpublished data
  • 2004
...
1
2
...