Serotonin syndrome and drug combinations: focus on MAOI and RIMA

@article{Hilton2009SerotoninSA,
  title={Serotonin syndrome and drug combinations: focus on MAOI and RIMA},
  author={S Hilton and H. Maradit and Hans-J{\"u}rgen M{\"o}ller},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2009},
  volume={247},
  pages={113-119}
}
Serotonin syndrome is a potentially life-threatening complication of psychopharmacological drug therapy. The syndrome is produced most often by the concurrent use of two or more drugs that increase brainstem serotonin activity and is often unrecognized because of the varied and nonspecific nature of its symptomatology. Serotonin syndrome is characterized by alterations in cognition, behavior, autonomic nervous system function and neuromuscular activity. The purpose of this study was to… Expand
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Author's Reply
because of his association with an established department of clinical toxicology and pharmacology that has had experience with many cases of serotonin syndrome. Isbister is absolutely correct thatExpand
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References

SHOWING 1-10 OF 56 REFERENCES
The Serotonin Syndrome
TLDR
Because fatalities and severe complications have accompanied the serotonin syndrome, the previously described drug combinations should be used cautiously or not at all. Expand
The serotonin syndrome.
  • H. Sternbach
  • Psychology, Medicine
  • The American journal of psychiatry
  • 1991
TLDR
The serotonin syndrome is a toxic condition requiring heightened clinical awareness for prevention, recognition, and prompt treatment, and further work is needed to establish the diagnostic criteria, incidence, and predisposing factors. Expand
Serotonin syndrome caused by a moclobemide-clomipramine interaction.
TLDR
A 7T year old woman with depression and Parkinson's disease has a case of serotonin syndrome induced by the reversible monoamine oxidase A inhibitor moclobemide and the serotonin reuptake inhibitor clomipramine, and fulfilled the diagnostic criteria for the serotonin syndrome suggested by Sternbach. Expand
Fatal Serotonin Syndrome following a Combined Overdose of Moclobemide, Clomipramine and Fluoxetine
TLDR
The case history of a patient who presented following overdose of moclobemide, clomipramine and fluoxetine and died from the subsequent complications of fulminant disseminated intravascular coagulation (DIC) and multiple organ failure. Expand
Pathophysiology and Management of the Serotonin Syndrome
TLDR
The SS is increasingly recognized and reported in the literature and clinical and basic science research have increased understanding of the pathophysiology, conditions, and agents that may predispose to the development of the syndrome. Expand
Prospective evaluation of the ‘Serotonin Syndrome’ in depressed patients treated with clomipramine
TLDR
The serotonin syndrome, induced by serotoninergic agents, includes confusion, agitation, myoclonus, diaphoresis, tremor and diarrhea, which prospectively evaluated in patients fullfilling DSM-III-R criteria for major depression. Expand
An update of recent moclobemide interaction data
  • J. Dingemanse
  • Chemistry, Medicine
  • International clinical psychopharmacology
  • 1993
TLDR
In combination with therapeutic doses of either fluvoxamine or fluoxetine, moclobemide did not provide any indication of a serotoninergic syndrome, so that no wash-out period is needed when switching from a selective serotonin re-uptake inhibitor to moclOBemide or vice versa. Expand
Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or “Ecstasy”)
TLDR
It is suggested that the recent increase in the number of reports of MDMA toxicity probably results from the widespread use of the drug at all night dance parties or “raves”, and suggestions for the rational treatment of the acute toxicity are made on the basis of both pharmacological studies in animals and current clinical practice. Expand
Prospective evaluation of the serotonin syndrome in depressed inpatients treated with clomipramine
The serotonin syndrome, induced by serotoninergic agents, includes confusion, agitation, myoclonus, diaphoresis, tremor and diarrhea. The authors prospectively evaluated all these symptoms in 38Expand
Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.
TLDR
Fluoxetine has overall therapeutic efficacy comparable with imipramine, amitriptyline and doxepin in patients with unipolar depression treated for 5 to 6 weeks, although it may be less effective than tricyclic antidepressants in relieving sleep disorders in depressed patients. Expand
...
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3
4
5
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