Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.

@article{Lee1999SerotoninSM,
  title={Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.},
  author={Sheu-Ling Lee and W. Wang and G. Finlay and B. Fanburg},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={1999},
  volume={277 2},
  pages={L282-L291}
}
  • Sheu-Ling Lee, W. Wang, +1 author B. Fanburg
  • Published 1999
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
  • Our previous studies have shown that, through an active transport process, serotonin (5-HT) rapidly elevates[Formula: see text] formation, stimulates protein phosphorylation, and enhances proliferation of bovine pulmonary artery smooth muscle cells (SMCs). We presently show that 1 μM 5-HT also rapidly elevates phosphorylation and activation of the mitogen-activated protein (MAP) kinases extracellular signal-regulated kinase (ERK) 1 and ERK2 of SMCs, and the enhanced phosphorylation is blocked… CONTINUE READING
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    References

    SHOWING 1-10 OF 47 REFERENCES
    Superoxide as an intermediate signal for serotonin-induced mitogenesis.
    • 116
    Ras Involvement in Signal Transduction by the Serotonin 5-HT2B Receptor (*)
    • 134
    • PDF
    Integration of mitogen-activated protein kinase kinase activation in vascular 5-hydroxytryptamine2A receptor signal transduction.
    • 79
    • PDF
    A synthetic inhibitor of the mitogen-activated protein kinase cascade.
    • 2,772
    • PDF