Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.
@article{Lee1999SerotoninSM, title={Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.}, author={Sheu-Ling Lee and W. Wang and G. Finlay and B. Fanburg}, journal={American journal of physiology. Lung cellular and molecular physiology}, year={1999}, volume={277 2}, pages={L282-L291} }
Our previous studies have shown that, through an active transport process, serotonin (5-HT) rapidly elevates[Formula: see text] formation, stimulates protein phosphorylation, and enhances proliferation of bovine pulmonary artery smooth muscle cells (SMCs). We presently show that 1 μM 5-HT also rapidly elevates phosphorylation and activation of the mitogen-activated protein (MAP) kinases extracellular signal-regulated kinase (ERK) 1 and ERK2 of SMCs, and the enhanced phosphorylation is blocked… CONTINUE READING
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