Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.
@article{Lee1999SerotoninSM, title={Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.}, author={S. L. Lee and W. Wang and G. Finlay and B. Fanburg}, journal={The American journal of physiology}, year={1999}, volume={277 2}, pages={ L282-91 } }
Our previous studies have shown that, through an active transport process, serotonin (5-HT) rapidly elevates O(-)(2). formation, stimulates protein phosphorylation, and enhances proliferation of bovine pulmonary artery smooth muscle cells (SMCs). We presently show that 1 microM 5-HT also rapidly elevates phosphorylation and activation of the mitogen-activated protein (MAP) kinases extracellular signal-regulated kinase (ERK) 1 and ERK2 of SMCs, and the enhanced phosphorylation is blocked by the… CONTINUE READING