Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.
@article{Lee1999SerotoninSM,
title={Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.},
author={Stephanie L. Lee and Warner W Wang and Geraldine A. Finlay and Barry L Fanburg},
journal={The American journal of physiology},
year={1999},
volume={277 2},
pages={
L282-91
}
}Our previous studies have shown that, through an active transport process, serotonin (5-HT) rapidly elevates O(-)(2). formation, stimulates protein phosphorylation, and enhances proliferation of bovine pulmonary artery smooth muscle cells (SMCs). We presently show that 1 microM 5-HT also rapidly elevates phosphorylation and activation of the mitogen-activated protein (MAP) kinases extracellular signal-regulated kinase (ERK) 1 and ERK2 of SMCs, and the enhanced phosphorylation is blocked by the… Expand
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