Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.

@article{Lee1999SerotoninSM,
  title={Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.},
  author={S. L. Lee and W. Wang and G. Finlay and B. Fanburg},
  journal={The American journal of physiology},
  year={1999},
  volume={277 2},
  pages={
          L282-91
        }
}
  • S. L. Lee, W. Wang, +1 author B. Fanburg
  • Published 1999
  • Biology, Medicine
  • The American journal of physiology
  • Our previous studies have shown that, through an active transport process, serotonin (5-HT) rapidly elevates O(-)(2). formation, stimulates protein phosphorylation, and enhances proliferation of bovine pulmonary artery smooth muscle cells (SMCs). We presently show that 1 microM 5-HT also rapidly elevates phosphorylation and activation of the mitogen-activated protein (MAP) kinases extracellular signal-regulated kinase (ERK) 1 and ERK2 of SMCs, and the enhanced phosphorylation is blocked by the… CONTINUE READING