Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.

@article{Lee1999SerotoninSM,
  title={Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.},
  author={Stephanie L. Lee and Warner W Wang and Geraldine A. Finlay and Barry L Fanburg},
  journal={The American journal of physiology},
  year={1999},
  volume={277 2},
  pages={
          L282-91
        }
}
Our previous studies have shown that, through an active transport process, serotonin (5-HT) rapidly elevates O(-)(2). formation, stimulates protein phosphorylation, and enhances proliferation of bovine pulmonary artery smooth muscle cells (SMCs). We presently show that 1 microM 5-HT also rapidly elevates phosphorylation and activation of the mitogen-activated protein (MAP) kinases extracellular signal-regulated kinase (ERK) 1 and ERK2 of SMCs, and the enhanced phosphorylation is blocked by the… Expand
2 Citations
Assessment of Platelet and Plasma Serotonin in Canine Pulmonary Hypertension Secondary to Degenerative Mitral Valve Disease
TLDR
A decrease in platelet serotonin concentration, which is associated with a degree of PH probability was found in DMVD dogs with PH, and further studies investigating roles of plateletotonin in PH secondary to DMVD should be performed. Expand
Role of TG2-Mediated SERCA2 Serotonylation on Hypoxic Pulmonary Vein Remodeling
TLDR
Investigation of the role of transglutaminases2 (TG2) as a key factor involved in SERCA2 serotonination and the effects of overexpression and downregulation of the TG2 gene on the activity of SER CA2, s-SERCA2, basal [Ca2+]i, and SOCE under normoxia and hypoxia in vitro and in vivo revealed a new target for treatment of chronic hypoxic pulmonary hypertension. Expand