Serotonin stimulates migrating myoelectric complex via 5-HT3-receptors dependent on cholinergic pathways in rat small intestine.

@article{Lrdal1999SerotoninSM,
  title={Serotonin stimulates migrating myoelectric complex via 5-HT3-receptors dependent on cholinergic pathways in rat small intestine.},
  author={Mikael L{\"o}rdal and Per M Hellstr{\"o}m},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={1999},
  volume={11 1},
  pages={1-10}
}
We have investigated the effect of 5-hydroxytryptamine (5-HT) and different 5-HT-receptor antagonists and atropine on the migrating myoelectric complex in the rat small intestine. Infusion of 5-HT dose-dependently shortened the interval between phase III of the migrating myoelectric complex (MMC). In untreated animals the interval in upper jejunum was 19.1 (16.0-22.1) min. At doses of 10 and 20 nmol kg-1 min-1, the interval decreased to 15.2 (12.0-18.4) and 10.2 (9.4-11.0) min, respectively… CONTINUE READING

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