Serotonin release varies with brain tryptophan levels

@article{Schaechter1990SerotoninRV,
  title={Serotonin release varies with brain tryptophan levels},
  author={Judith D. Schaechter and Richard J. Wurtman},
  journal={Brain Research},
  year={1990},
  volume={532},
  pages={203-210}
}

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References

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Tryptophan Availability Modulates Serotonin Release from Rat Hypothalamic Slices
TLDR
The data suggest that the rate at which serotonin is released from hypothalamic nerve terminals is coupled to brain tryptophan levels, which results in proportionate increases in the rates of serotonin release during rest and with membrane depolarization.
Vasopressin augments depolarization-induced release and synthesis of serotonin in hippocampal slices
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TLDR
The data show that vasopressin acts on a specific group of hippocampal nerve endings to increase serotonin synthesis, and the resulting increase in tissue serotonin may be the factor leading to the observed increase in serotonin release.
Regulation of Serotonin Release from the In Vitro Rat Hippocampus: Effects of Alterations in Levels of Depolarization and in Rates of Serotonin Metabolism
TLDR
Results support the kinetic model and suggest that regulation of 5‐HT metabolism at the site of the nerve terminal could be a mechanism for modulation of 5-HT release during prolonged discharge of serotonergic neurons.
Diabetes-Related Changes in L-Tryptophan–Induced Release of Striatal Biogenic Amines
TLDR
In acutely diabetic and normal rats, L-tryptophan administration reduced striatal dopamine and increased striatal serotonin release, whereas in chronically diabetic rats, the release of both biogenic amines was decreased.
Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels
TLDR
Brain serotonin cocentrations at 1 p.m. were significantly elevated 1 hour after rats received a dose of L-tryptophan and plasma and brain tryptophan levels were elevated 10 to 60 minutes after the injection, but they never exceeded the concentrationis that occur nocturnally in untreated aninmals as result of their normal 24-hour rhythms.
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