Serotonin release varies with brain tryptophan levels

@article{Schaechter1990SerotoninRV,
  title={Serotonin release varies with brain tryptophan levels},
  author={J. Schaechter and R. Wurtman},
  journal={Brain Research},
  year={1990},
  volume={532},
  pages={203-210}
}
This study examines directly the effects on serotonin release of varying brain tryptophan levels within the physiologic range. It also addresses possible interactions between tryptophan availability and frequency of membrane depolarization in controlling serotonin release. We demonstrate that reducing tryptophan levels in rat hypothalamic slices (by superfusing them with medium supplemented with 100 microM leucine) decreases tissue serotonin levels as well as both spontaneous and electrically… Expand
154 Citations
Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
Role of tryptophan in the elevated serotonin-turnover in hepatic encephalopathy
Effects of Rapid Tryptophan Depletion on Sleep Electroencephalogram and Mood in Subjects with Partially Remitted Depression on Bupropion
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 145 REFERENCES
Vasopressin augments depolarization-induced release and synthesis of serotonin in hippocampal slices
  • S. Auerbach, P. Lipton
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1982
...
1
2
3
4
5
...