5-Hydroxytryptamine (serotonin) in the gastrointestinal tract
- BiologyCurrent opinion in endocrinology, diabetes, and obesity
New studies show that enteric 5-HT is a polyfunctional signalling molecule, acting both in developing and mature animals as a neurotransmitter paracrine factor, endocrine hormone and growth factor.
The Cornucopia of Intestinal Chemosensory Transduction
- BiologyFront. Neurosci.
The idea that chemosensory transduction mechanisms in the GI tract utilise many overlapping and complementary mechanisms for detecting and transducing stimuli into reflex action is highlighted.
Clostridium ramosum regulates enterochromaffin cell development and serotonin release
- BiologyScientific Reports
It is demonstrated that bacterial cell components stimulate host 5- HT secretion and program the differentiation of colonic intestinal stem progenitors toward the secretory 5-HT-producing lineage, suggesting that the presence of C. ramosum in the gut promotes 5-hydroxytryptamine secretion and thereby could facilitates intestinal lipid absorption and the development of obesity.
The Mechanism of Secretion and Metabolism of Gut-Derived 5-Hydroxytryptamine
- BiologyInternational journal of molecular sciences
Recent evidence is reviewed to recapitulate the mechanisms of synthesis, secretion, regulation, and biofunction of 5-HT to improve the nutrition and health of humans.
Serotonin and its Functions as Gastrointestinal Hormone
- Medicine, Biology
The localization of serotonin-producing EC cells, their ultrastructural characteristics and the presence and distribution of serotonin receptor 5HTR3 in the stomach are investigated in order to obtain a better understanding of the functional role of serotonin.
The Multifaceted Role of Serotonin in Intestinal Homeostasis
- BiologyInternational journal of molecular sciences
An inventory of intestinal immune and epithelial cells that respond to 5-HT is presented and the effects of these signaling processes on intestinal homeostasis are described and detail the mechanisms by which 5- HT could affect inflammatory bowel disease course.
Interaction between diet and gastrointestinal endocrine cells
- Biology, MedicineBiomedical reports
The interaction between ingested foodstuffs and the gastrointestinal endocrine cells can be utilized for the clinical management of gastrointestinal and metabolic diseases, such as irritable bowel syndrome, obesity and diabetes.
The role of serotonin and its receptors in activation of immune responses and inflammation
- BiologyActa physiologica
An update on the role of 5‐HT in biological functions with a particular focus on immune activation and inflammation is provided.
Mast cell expression of the serotonin1A receptor in guinea pig and human intestine.
- Biology, MedicineAmerican journal of physiology. Gastrointestinal and liver physiology
The hypothesis that elevation of 5-HT in the environment of enteric mast cells might degranulate the mast cells and release mediators that become paracrine signals to the enteric nervous system, spinal afferents, and secretory glands is supported.
SHOWING 1-10 OF 142 REFERENCES
5-HT system in the gut: roles in the regulation of visceral sensitivity and motor functions.
- Biology, MedicineEuropean review for medical and pharmacological sciences
Current evidence suggests that the bioavailability of 5- HT within the gut wall is altered in a number of post-inflammatory models of gut dysfunction with increased numbers of EC cells and mast cells with increased 5-HT content in proximity to sensory nerve endings, and decreased serotonin reuptake mechanisms.
TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
- Biology, ChemistryProceedings of the National Academy of Sciences
It is demonstrated that the transient receptor potential (TRP) cation channel TRPA1, which is activated by pungent compounds or cold temperature, is highly expressed in EC cells, and that allyl isothiocyanate promotes the contraction of isolated guinea pig ileum via the 5-HT3 receptor.
Effects of gastrointestinal inflammation on enteroendocrine cells and enteric neural reflex circuits
- BiologyAutonomic Neuroscience
Sensory transmission in the gastrointestinal tract
- BiologyNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
The purpose of this review is to summarize current views on sensory processing within both the enteric and extrinsic innervation and to specifically address the pharmacology of nociceptive extrinsics sensory pathways.
Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract
- BiologyThe Journal of neuroscience : the official journal of the Society for Neuroscience
In the current investigation, desensitization of 5-HT receptors was demonstrated to inhibit the peristaltic reflex in the guinea pig large intestine in vitro, suggesting that the peristsaltic Reflex depends on the 5- HT transporter-mediated inactivation of5-HT.
Review article: serotonin receptors and transporters — roles in normal and abnormal gastrointestinal motility
- Biology, MedicineAlimentary pharmacology & therapeutics
The gut is the only organ that can display reflexes and integrative neuronal activity even when isolated from the central nervous system, and the observation that molecular defects occur in the human gut in irritable bowel syndrome strengthens the hand of those seeking to legitimize the disease.
Regulation of 5-HT release from enterochromaffin cells
- BiologyBehavioural Brain Research
ATP and Sensory Transduction in the Enteric Nervous System
- BiologyThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
ATP participates in the transduction of sensory stimuli from the gut lumen and in the subsequent initiation and propagation of enteric reflexes, and may act as a sensory mediator, from epithelial sources to the intrinsic sensory nerve terminals.
On the presence of serotonin in the gut lumen and possible release mechanisms.
- BiologyActa physiologica Scandinavica
The experiments demonstrate that 5- HTP is taken up not only into typical EC but also into other enteroendocrine cells, and most probably decarboxylated to 5-HT.
The serotonin signaling system: from basic understanding to drug development for functional GI disorders.
- Biology, MedicineGastroenterology
The initial success encountered with serotonergic agents holds promise for newer and more potent insights and therapies of brain-gut disorders.