Serotonin release and phosphoinositide breakdown in thrombin-induced activation of human platelets.

Abstract

The release reaction and the metabolism of inositol lipids were studied in parallel in washed human platelets following the activation by low doses of thrombin. The breakdown of phosphatidylinositol 4,5-bisphosphate (PI-P2) was accompanied by the release of serotonin. These events preceded the breakdown of the other phosphoinositides and the release of… (More)

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Cite this paper

@article{Marche1985SerotoninRA, title={Serotonin release and phosphoinositide breakdown in thrombin-induced activation of human platelets.}, author={P. Marche and Francine Rendu and Jacques Maclouf and Arlette Girard and Sylviane L{\'e}vy-Toledano}, journal={Journal of cardiovascular pharmacology}, year={1985}, volume={7 Suppl 7}, pages={S18-9} }