Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor.

@article{Laplante2002SerotoninRH,
  title={Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor.},
  author={Patricia Laplante and Josie C Diorio and Michael J. Meaney},
  journal={Brain research. Developmental brain research},
  year={2002},
  volume={139 2},
  pages={
          199-203
        }
}
Glucocorticoid receptor expression in primary hippocampal cell cultures was significantly increased with either 10 mM 8-bromo cAMP, 50 nM 5-carboxamidotryptamine (5-CT), a potent 5-HT7 receptor agonist, or 100 nM 5-HT. The effect of 5-HT or 5-CT was blocked with methiothepin or by a protein kinase A inhibitor, but not pindolol. These results suggest that the effects of 5-HT on hippocampal GR expression is mediated by a 5-HT7 receptor. 
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