Serotonin regulates calcium homeostasis in lactation by epigenetic activation of hedgehog signaling.

@article{Laporta2014SerotoninRC,
  title={Serotonin regulates calcium homeostasis in lactation by epigenetic activation of hedgehog signaling.},
  author={Jimena Laporta and Kimberly P. Keil and Samantha R. Weaver and Callyssa M Cronick and Austin P. Prichard and Thomas D. Crenshaw and Galen W. Heyne and Chad M Vezina and Robert J Lipinski and Laura L Hernandez},
  journal={Molecular endocrinology},
  year={2014},
  volume={28 11},
  pages={1866-74}
}
Calcium homeostasis during lactation is critical for maternal and neonatal health. We previously showed that nonneuronal/peripheral serotonin [5-hydroxytryptamine (5-HT)] causes the lactating mammary gland to synthesize and secrete PTHrP in an acute fashion. Here, using a mouse model, we found that genetic inactivation of tryptophan hydroxylase 1 (Tph1), which catalyzes the rate-limiting step in peripheral 5-HT synthesis, reduced circulating and mammary PTHrP expression, osteoclast activity… CONTINUE READING
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