Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms.

  title={Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms.},
  author={Supriya Srinivasan and Leila Sadegh and Ida Coordt Elle and Anne G L Christensen and Nils Joakim Faergeman and Kaveh Ashrafi},
  journal={Cell metabolism},
  volume={7 6},
We investigated serotonin signaling in C. elegans as a paradigm for neural regulation of energy balance and found that serotonergic regulation of fat is molecularly distinct from feeding regulation. Serotonergic feeding regulation is mediated by receptors whose functions are not required for fat regulation. Serotonergic fat regulation is dependent on a neurally expressed channel and a G protein-coupled receptor that initiate signaling cascades that ultimately promote lipid breakdown at… CONTINUE READING
68 Citations
62 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 68 extracted citations


Publications referenced by this paper.
Showing 1-10 of 62 references

Metabolism at a Glance, Second Edition (Oxford: Blackwell Scientific)

  • J. G. Salway
  • 1999
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…