Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity

@article{Murakami2007SerotoninRA,
  title={Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity},
  author={Hana Murakami and S. Murakami},
  journal={Aging Cell},
  year={2007},
  volume={6}
}
  • Hana Murakami, S. Murakami
  • Published 2007
  • Biology, Medicine
  • Aging Cell
  • The neurotransmitter serotonin has been implicated in affecting the variation of longevity in natural Drosophila populations and age‐related diseases in mammals. Based on these observations, it has been predicted that serotonin signal, perhaps at levels of serotonin biosynthesis, may control lifespan. Here, we investigated a variety of mutations in serotonin‐signal genes, including serotonin biosynthesis genes, a serotonin transporter gene, and serotonin receptor genes. Despite this prediction… CONTINUE READING
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