Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity

  title={Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity},
  author={Hana Murakami and S. Murakami},
  journal={Aging Cell},
  • Hana Murakami, S. Murakami
  • Published 2007
  • Biology, Medicine
  • Aging Cell
  • The neurotransmitter serotonin has been implicated in affecting the variation of longevity in natural Drosophila populations and age‐related diseases in mammals. Based on these observations, it has been predicted that serotonin signal, perhaps at levels of serotonin biosynthesis, may control lifespan. Here, we investigated a variety of mutations in serotonin‐signal genes, including serotonin biosynthesis genes, a serotonin transporter gene, and serotonin receptor genes. Despite this prediction… CONTINUE READING
    41 Citations
    A High‐Throughput Screen for Chemicals that Increase the Lifespan of Caenorhabditis elegans
    • 38
    A Genetic Survey of Fluoxetine Action on Synaptic Transmission in Caenorhabditis elegans
    • 36
    • PDF
    A pharmacological network for lifespan extension in Caenorhabditis elegans
    • 86
    • PDF
    Endocrine regulation of aging and reproduction in Drosophila
    • 133
    C. elegans dauer formation and the molecular basis of plasticity.
    • 415
    • PDF


    Characterization of a Novel Serotonin Receptor from Caenorhabditis elegans
    • 102
    Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses.
    • 81
    Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans
    • C. Loer, C. Kenyon
    • Biology, Medicine
    • The Journal of neuroscience : the official journal of the Society for Neuroscience
    • 1993
    • 254
    • PDF
    Fitness cost of extended lifespan in Caenorhabditis elegans
    • 141
    A systematic RNAi screen for longevity genes in C. elegans.
    • 481
    • PDF