Serotonin receptor sensitivity after acute and chronic treatment with mianserin.
@article{Blackshear1982SerotoninRS,
title={Serotonin receptor sensitivity after acute and chronic treatment with mianserin.},
author={M. A. Blackshear and E. sanders-Bush},
journal={The Journal of pharmacology and experimental therapeutics},
year={1982},
volume={221 2},
pages={
303-8
}
}The chronic administration of mianserin for 14 days leads to a marked decrease in the maximal number of serotonin2 (5-HT2) binding sites in brains of rats and mice with no change in the KD values. The decrease in [3H]spiroperidol binding to the 5-HT2 site in rats was most pronounced in the frontal cortex with only minor changes in hippocampus and pons-medulla. The 5-HT1 site was largely unaffected. The decrease in the Bmax for 5-HT2 site also occurred after a single dose of mianserin, although… CONTINUE READING
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