Corpus ID: 33763347

Serotonin receptor sensitivity after acute and chronic treatment with mianserin.

@article{Blackshear1982SerotoninRS,
  title={Serotonin receptor sensitivity after acute and chronic treatment with mianserin.},
  author={M. A. Blackshear and E. sanders-Bush},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1982},
  volume={221 2},
  pages={
          303-8
        }
}
  • M. A. Blackshear, E. sanders-Bush
  • Published 1982
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • The chronic administration of mianserin for 14 days leads to a marked decrease in the maximal number of serotonin2 (5-HT2) binding sites in brains of rats and mice with no change in the KD values. The decrease in [3H]spiroperidol binding to the 5-HT2 site in rats was most pronounced in the frontal cortex with only minor changes in hippocampus and pons-medulla. The 5-HT1 site was largely unaffected. The decrease in the Bmax for 5-HT2 site also occurred after a single dose of mianserin, although… CONTINUE READING
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