Serotonin pharmacology in the gastrointestinal tract: a review

@article{Beattie2008SerotoninPI,
  title={Serotonin pharmacology in the gastrointestinal tract: a review},
  author={David T. Beattie and J. A. M. Smith},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2008},
  volume={377},
  pages={181-203}
}
  • D. Beattie, J. A. Smith
  • Published 9 April 2008
  • Biology, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
Serotonin (5-hydroxytryptamine or 5-HT) plays a critical physiological role in the regulation of gastrointestinal (GI) function. 5-HT dysfunction may also be involved in the pathophysiology of a number of functional GI disorders, such as chronic constipation, irritable bowel syndrome and functional dyspepsia. This article describes the role of 5-HT in the enteric nervous system (ENS) of the mammalian GI tract and the receptors with which it interacts. Existing serotonergic therapies that have… 
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101 Citations

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Citation Type

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The suitability of the 5-HT3 and5-HT4 receptors as therapeutic targets for management of functional GI disorder (FGID) has been investigated for clinical purposes and recently 5HT7 has garnered attention as a possible therapeutic target.
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Current knowledge on the impact of genetics and pharmacogenetics of aminergic pathways on FGID pathophysiology, clinical presentations, symptom severity and medical management is reviewed in an attempt of highlighting the most relevant evidence and point out issues that should be addressed in future investigations.
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Constipation, IBs and the 5-HT4 Receptor: What Role for Prucalopride?
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Prucalopride is now the first of a new class of drug defined by selectivity and high intrinsic activity at the 5-HT4 receptor, characterized by good selectivity at the5-HT 4 receptor, high intrinsicactivity and efficacy in patients with chronic constipation.
The 5-HT7 receptor and disorders of the nervous system: an overview
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The use of pharmacological and genetic tools in preclinical animal models strongly supports a role for the 5-HT7 receptor in depression and indirect evidence exists showing that 5- HT7 receptor antagonism is clinically useful in the treatment of depression.
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