Serotonin pharmacology in the gastrointestinal tract: a review
@article{Beattie2008SerotoninPI, title={Serotonin pharmacology in the gastrointestinal tract: a review}, author={D. Beattie and J. Smith}, journal={Naunyn-Schmiedeberg's Archives of Pharmacology}, year={2008}, volume={377}, pages={181-203} }
Serotonin (5-hydroxytryptamine or 5-HT) plays a critical physiological role in the regulation of gastrointestinal (GI) function. 5-HT dysfunction may also be involved in the pathophysiology of a number of functional GI disorders, such as chronic constipation, irritable bowel syndrome and functional dyspepsia. This article describes the role of 5-HT in the enteric nervous system (ENS) of the mammalian GI tract and the receptors with which it interacts. Existing serotonergic therapies that have… CONTINUE READING
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