• DOI:10.1007/s00210-008-0276-9
Corpus ID: 32820765

Serotonin pharmacology in the gastrointestinal tract: a review

@article{Beattie2008SerotoninPI,
  title={Serotonin pharmacology in the gastrointestinal tract: a review},
  author={D. Beattie and J. Smith},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2008},
  volume={377},
  pages={181-203}
}

D. Beattie, J. Smith

Published 2008

Medicine, Chemistry

Naunyn-Schmiedeberg's Archives of Pharmacology

Serotonin (5-hydroxytryptamine or 5-HT) plays a critical physiological role in the regulation of gastrointestinal (GI) function. 5-HT dysfunction may also be involved in the pathophysiology of a number of functional GI disorders, such as chronic constipation, irritable bowel syndrome and functional dyspepsia. This article describes the role of 5-HT in the enteric nervous system (ENS) of the mammalian GI tract and the receptors with which it interacts. Existing serotonergic therapies that have… CONTINUE READING

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