Serotonin pharmacology in the gastrointestinal tract: a review

@article{Beattie2008SerotoninPI,
  title={Serotonin pharmacology in the gastrointestinal tract: a review},
  author={David T. Beattie and J. A. M. Smith},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2008},
  volume={377},
  pages={181-203}
}
  • D. Beattie, J. A. Smith
  • Published 9 April 2008
  • Biology, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
Serotonin (5-hydroxytryptamine or 5-HT) plays a critical physiological role in the regulation of gastrointestinal (GI) function. 5-HT dysfunction may also be involved in the pathophysiology of a number of functional GI disorders, such as chronic constipation, irritable bowel syndrome and functional dyspepsia. This article describes the role of 5-HT in the enteric nervous system (ENS) of the mammalian GI tract and the receptors with which it interacts. Existing serotonergic therapies that have… 
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References

SHOWING 1-10 OF 321 REFERENCES
Serotonin and Its Role in Colonic Function and in Gastrointestinal Disorders
TLDR
This review summarizes the current medications affecting serotonin signaling and provides an overview of the current knowledge of the changes in serotonin that occur in pathologic conditions.
The importance of 5-hydroxytryptamine receptors in the gut.
Rationale for using serotonergic agents to treat irritable bowel syndrome.
  • D. Baker
  • Medicine
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2005
TLDR
The use of serotonergic agents in patients with IBS is based on the critical role that serotonin plays in the maintenance of normal gut function and brain-gut communication.
5‐Hydroxytryptamine effects in the gut: the 3, 4, and 7 receptors
  • M. Tonini
  • Biology, Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2005
TLDR
Some expected and unexpected effects of tegaserod, a partial 5-HT4 receptor agonist, on gastric emptying in a murine model of diabetes mellitus are observed and the role on gut function of 6-HT7 receptors is outlined, the most recently characterized members of the5-HT receptor family.
Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse
TLDR
It is demonstrated that reduced SERT function (via pharmacological blockade) significantly alters GI motility and sensitivity in mice, and support the concept that altered SERT expression and function could contribute to symptoms associated with IBS and IBD.
Serotonin: a mediator of the brain–gut connection
TLDR
The goal in this review is to provide the reader with an understanding of the basic physiology of serotonin, a mediator of the brain–gut connection, serotonin receptor subtypes, the role of serotonin in diseases of the gut, and the potential role of agonists and antagonists in GI clinical therapeutics.
5‐HT2B receptors play a key role in mediating the excitatory effects of 5‐HT in human colon in vitro
TLDR
This study has shown for the first time that, in contrast to animal studies, the excitatory effects of 5‐HT in human colon are mediated by5‐HT2B receptors, and proposed that these receptors contribute to the putative 5‐ HT‐induced colonic smooth muscle hypersensitivity associated with IBS.
Review article: the therapeutic potential of 5‐HT3 receptor antagonists in the treatment of irritable bowel syndrome
TLDR
If this concept is validated, it will provide a rationale for the use of 5‐HT3 receptor antagonists in patients with increased gut motility, reduced fluid absorption and low nociceptive thresholds leading to abdominal pain.
Effects of a serotonin 5-HT4 receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans
TLDR
5-HT4receptors are involved in the regulation of cisapride stimulated orocaecal transit; SB 207266 tends to modulate colonic transit but not sensory functions or compliance in healthy human subjects.
Expression of 5-HT3 receptors in the rat gastrointestinal tract.
TLDR
Findings indicate that 5-HT3Rs are expressed by distinct cells in the GI tract, including functionally distinct classes of neurons, interstitial cells of Cajal, and endocrine cells.
...
1
2
3
4
5
...