Serotonin pharmacology in the gastrointestinal tract: a review

  title={Serotonin pharmacology in the gastrointestinal tract: a review},
  author={D. Beattie and J. Smith},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  • D. Beattie, J. Smith
  • Published 2008
  • Medicine, Chemistry
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • Serotonin (5-hydroxytryptamine or 5-HT) plays a critical physiological role in the regulation of gastrointestinal (GI) function. 5-HT dysfunction may also be involved in the pathophysiology of a number of functional GI disorders, such as chronic constipation, irritable bowel syndrome and functional dyspepsia. This article describes the role of 5-HT in the enteric nervous system (ENS) of the mammalian GI tract and the receptors with which it interacts. Existing serotonergic therapies that have… CONTINUE READING
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