• Psychology, Medicine
  • Published in
    The Journal of clinical…
    1987

Serotonin-norepinephrine receptor interactions in the brain: implications for the pharmacology and pathophysiology of affective disorders.

@article{Sulser1987SerotoninnorepinephrineRI,
  title={Serotonin-norepinephrine receptor interactions in the brain: implications for the pharmacology and pathophysiology of affective disorders.},
  author={Fridolin Sulser},
  journal={The Journal of clinical psychiatry},
  year={1987},
  volume={48 Suppl},
  pages={
          12-8
        }
}
When chronically administered, most clinically effective antidepressant treatments (pharmacotherapy and ECT) reduce the sensitivity of the norepinephrine-sensitive adenylate cyclase in brain which, in turn, is associated with a down-regulation of the beta-adrenoceptor subpopulation. Because this norepinephrine receptor system is linked to an amplifier system, small changes in the number of receptors or in the accumulation of the second messenger cyclic AMP will be amplified. Results of the… CONTINUE READING

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