Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects.

@article{Smith2002SerotoninMO,
  title={Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects.},
  author={Gwenn S. Smith and Yilong Ma and Vijay Dhawan and Handan G{\"u}nd{\"u}z and M. Carbon and Maggie Kirshner and Jennifer Sue Larson and Thomas C Chaly and Abdel Belakhleff and Elisse Kramer and Blaine S. Greenwald and John M. Kane and Fouzia Laghrissi-Thode and Bruce G. Pollock and David Eidelber},
  journal={Synapse},
  year={2002},
  volume={45 2},
  pages={
          105-12
        }
}
To develop a method to measure the dynamic response of the serotonin system in vivo, the effects of intravenously administered citalopram (the most selective of the serotonin reuptake inhibitors) on cerebral glucose metabolism were evaluated. Cerebral glucose metabolism was measured with positron emission tomography (PET) in 14 normal subjects scanned after administration of saline placebo and citalopram administered on 2 separate days. Citalopram administration resulted in a decrease in… CONTINUE READING
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