Serotonin model of schizophrenia: emerging role of glutamate mechanisms

@article{Aghajanian2000SerotoninMO,
  title={Serotonin model of schizophrenia: emerging role of glutamate mechanisms},
  author={G. Aghajanian and G. Marek},
  journal={Brain Research Reviews},
  year={2000},
  volume={31},
  pages={302-312}
}
The serotonin (5-HT) hypothesis of schizophrenia arose from early studies on interactions between the hallucinogenic drug LSD (D-lysergic acid diethylamide) and 5-HT in peripheral systems. More recent studies have shown that the two major classes of psychedelic hallucinogens, the indoleamines (e.g., LSD) and phenethylamines (e.g. , mescaline), produce their central effects through a common action upon 5-HT(2) receptors. This review focuses on two brain regions, the locus coeruleus and the… Expand
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