Serotonin mediates beneficial effects of Hypericum perforatum on nicotine withdrawal signs.

@article{Mannucci2007SerotoninMB,
  title={Serotonin mediates beneficial effects of Hypericum perforatum on nicotine withdrawal signs.},
  author={Carmen Mannucci and Antonella Pieratti and Fabio Firenzuoli and Achille Patrizio Caputi and Gioacchino Calapai},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2007},
  volume={14 10},
  pages={645-51}
}
Antidepressants may be effective treatment for smoking cessation and new evidence on relationship between smoking and depression is emerging. Extracts of the plant Hypericum perforatum possess antidepressant activity in humans and reduce nicotine withdrawal signs in mice. Both nicotine and H. perforatum administration elicit changes in serotonin (5-HT) formation in the brain. On this basis, we investigated the possible involvement of 5-HT in the beneficial effects of H. perforatum on nicotine… CONTINUE READING