Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization.

@article{Iyer1996SerotoninmediatedII,
  title={Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization.},
  author={R. N. Iyer and Charles W. Bradberry},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={277 1},
  pages={40-7}
}
Interactions between serotonin (5-HT) and dopamine (DA) neuronal systems in the prefrontal cortex (PFC) may be important in the pathophysiology of cognitive disorders such as schizophrenia. We have examined the effect of 5-HT, applied locally through a microdialysis probe, on extracellular DA in the PFC, and compared the response to that observed in the striatum. 5-HT in concentrations of 1 to 10 microM increased extracellular DA dose-dependently to a greater extent in the PFC than in the… CONTINUE READING

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